Sensitivity of Influenza A/New Jersey/8/76 (HswlNl) Virus to Amantadine●HCI
Identifieur interne : 002A54 ( Main/Exploration ); précédent : 002A53; suivant : 002A55Sensitivity of Influenza A/New Jersey/8/76 (HswlNl) Virus to Amantadine●HCI
Auteurs : R. R. Grunert [États-Unis] ; C. E. Hoffmann [États-Unis]Source :
- Journal of Infectious Diseases [ 0022-1899 ] ; 1977.
Abstract
The appearance of a swine type of influenza A among recruits in Fort Dix, New Jersey, in 1976 prompted an evaluation of the sensitivity of this virus to amantadine ● HCl. Well-tolerated levels of the drug effectively blocked replication of the influenza A/New Jersey/8/76 (HswlNI) virus isolate in three laboratory models: monkey kidney cells, embryonated eggs, and intranasally infected mice. On a comparative basis this virus would appear to be more sensitive to amantadine ● HCl than human influenza A strains, including the recent Victoria (1975) strain. All strains of influenza A virus continue to be sensitive to amantadine ● HCl.
Url:
DOI: 10.1093/infdis/136.2.297
Affiliations:
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